Drug Testing Laboratory Practice Test

These questions are part of the practice quiz. Start practicing

• Which specimen's storage is described as a cool and dry place?
• For which type of compounds is LC-MS/MS particularly advantageous in confirmatory testing?
• Immunoassay positive but GC-MS negative: what is the recommended action?
• Which specimen requires prolonged storage at -20°C?
• What are the typical components of a laboratory quality management system for a drug testing lab?
• Which LIMS feature is most directly tied to maintaining an unalterable record of actions?
• Can the ASC allow the client to select the collection container from the available supplies?
• Describe the typical workflow from specimen receipt to result reporting in a drug testing lab?
• Which term best describes specimen collection at a location separate from the main laboratory?
• SPX can be tested for additional drugs upon request, depending on the
• What does LIMS stand for in laboratory settings?
• Which technique is typically used for initial screening in drug testing laboratories?
• Which of the following is listed as not authorized to collect specimens?
• What does DOH stand for?
• Explain the difference between a screening positive and a confirmatory positive result in drug testing.
• For a specimen reported as negative, what is the minimum retention period?
• Which term best describes specimen collection conducted away from the main laboratory?
• Which statement describes the DOH standard electronic lab report?
• What is the storage instruction for urine when storing for a prolonged period?
• Which documents are typically submitted with a screening specimen?
• RA 9165 is commonly known as which act?
• What is the purpose of a reflex testing protocol in urine drug testing?
• What is the purpose of measuring specific gravity in urine drug testing?
• Which items are essential safety considerations in handling hazardous chemicals and biological samples in a drug testing lab?
• Which roles are listed as acceptable for Head of the Laboratory (Confirmatory)?
• Which item is used for confirmatory testing and is often registered with health authorities?
• If a sample tests positive on an immunoassay but negative on confirmatory GC-MS, what is a reasonable next step?
• Explain how isotopically labeled internal standards help address matrix-effects in LC-MS/MS.
• The DTL must secure a permit from which authority prior to a scheduled activity?
• Which of the following statements about the 24-hour release is true?
• How many days prior to the scheduled activity must the DTL secure a permit from HSFRB/CHD?
• Which term describes a designated area within the lab or a temporary facility located at a remote site?
• Which statement best describes specificity and selectivity in method validation?
• If a screening test is positive but confirmatory testing is negative, what is the appropriate next step?
• For the physician credential in Screening, how many years of active lab experience in analytical toxicology are required?
• Which item is included in calibration/maintenance records to monitor equipment lifespan?
• Failure of which entity to sign CCF contributes to rejection?
• In method validation, how is percent recovery calculated?
• Which item is not one of the three mandatory chain-of-custody elements?
• What does the term "+neat" indicate for saliva (oral fluid), tissue, or fingernails specimens?
• Which method is immunoassay-based used for screening?
• Which technique is commonly used for preliminary screening in drug testing laboratories?
• Which credential is explicitly listed for the Head of the Laboratory (Screening)?
• GC-MS identity confirmation: what supports identification besides retention time tolerance?
• Which practices are essential to prevent sample mix-ups in labeling and tube types?
• Which of the following is a valid reason to flag a specimen for invalidation during transport?
• Which organization is associated with signing the Memorandum for Record (MFR)?
• Which credential is listed for the Head of the Laboratory (Confirmatory)?
• What are common adulterants used to dilute urine and how can labs detect them?
• Which describes the proficiency testing result review by a supervisor?
• For tampered specimens, when should you list any prescription/medication taken in the past two weeks?
• Differentiate between accuracy and precision in method validation.
• Which of the following timeframes could be considered longer than 24 hours for releasing results?
• What is the purpose of a chain-of-custody log in sample handling?
• Which LIMS feature is most directly tied to maintaining an unalterable record of actions?
• Which of the following is the correct minimum quantity for a blood specimen?
• Which practice helps prevent false positives due to carryover?
• Which specimen requires deep freezing at -8 to -10°C?
• Adulterated, substituted, or invalid results must be kept in a second location.
• What is the difference between a 'positive' and an 'invalid' result in toxicology testing?
• What elements are essential in specimen handling to ensure integrity and traceability in federally regulated drug testing?
• Explain the purpose of using isotopically labeled internal standards in quantitative LC-MS/MS assays.
• What is the primary purpose of calibration in LC-MS/MS analysis?
• Which organization approval is referenced for using testing kits in this context?
• Which statement about observed urine collection is true?
• Which credential is listed for the Head of the Laboratory (Confirmatory)?
• Which of the following represents the full list of allowable conditionals for a remote collection site?
• What does TLC stand for in chromatography?
• Which action is used to detect tampering, substitutions, adulteration, or dilution in specimen collection?
• What is matrix effect in LC-MS/MS and how can it be mitigated?
• If a screening result is not retrieved by the client/donor/subject, after how many days may the laboratory discard the specimen?
• What are cutoffs, and why are they essential in screening immunoassays?
• Retraining of an Authorized Specimen Collector is due to which parties?
• Which option best describes the overall theme of the material?
• What is the minimum quantity required for a saliva specimen?
• Prior to sealing all specimen containers, what must be done by the ASC and client/donor/subject?
• What is a proficiency testing program and why is it important?
• If the collection device is unique and integral part of the collection and analytical testing procedure, it must be registered by the appropriate agency designated by which as a medical device?
• Selectivity in LC-MS/MS is defined as the ability to distinguish the target analyte from matrix components. Which option best represents this concept?
• The DOH electronic lab report should be complete with all required data elements.
• Which major analytical techniques are used for initial screening and confirmatory testing in drug testing laboratories?
• Which specimen type is described as being immediately frozen and transported in a clean, dry, tightly capped plastic container with no additives?
• Why is a calibration verification step important between calibration curves in quantitative assays?
• Regarding urine specimen collection, when should handwashing be performed?
• What is the minimum number of days mentioned for cancellation?
• Custody and Control Form (CCF) is used to document which process?
• Which of the following is a chromatographic technique?
• Which of the following is typically used to request a confirmatory test after screening?
• If a 3-5 working days window applies, what is the maximum deadline for release in those cases?
• For urine storage not exceeding 1 day, what is the recommended temperature?
• According to the procedures in which document should all equipment be calibrated and maintained?
• What is the purpose of a validity test in GC-MS/LC-MS/MS confirmation runs?
• Which organization designates a medical device for registration?
• How should tissue be stored?
• An alternative release window sometimes used for Confirmatory Lab results is which of the following?
• The term 'working days' in laboratory turnaround times most commonly excludes which of the following?
• How is the limit of quantitation (LOQ) determined experimentally in quantitative assays?
• TRUE OR FALSE: Single-use items are not unique collection devices and are not required to be registered or cleared by the Department of Health.
• Which factor is most directly used to determine if a urine specimen is tampered with?
• Which specimens require a 200 mg capacity collection device?
• Which error involves failing to check and record the SPX temperature with appropriate remarks?
• What document is used to document chain of custody from the time a sample is collected to testing?
• Which item is listed as an exception for mandatory drug testing (facility and permit)?
• When courier services are used for specimen transport, what details must be documented on the chain of custody form (CCF)?
• If a sample's immunoassay signal is above the cutoff, what does it indicate?
• Selectivity example in LC-MS/MS.
• Hair testing detection and analysis typically uses which analytical technique?
• Which document is used to record a correctable reason for SPX rejection?
• Which description correctly explains 'working days' in the context of lab turnarounds?
• What is the quantity of the primary saliva specimen?
• Why is it important to document instrument maintenance and performance checks?
• The 24-hour release window is most consistent with which operational priority?
• Collection of specimen for all mandatory drug testing (for example, under RA 9165) shall be done at which type of facility?
• If a laboratory uses both 24-hour and 3-5 day windows, which statement best describes the policy?
• For a specimen with a positive, adulterated, substituted, or invalid result, what is the maximum retention period?
• What is a calibration curve and why must it be linear over the calibrated range?
• Which factor can constitute an exception for mandatory drug testing (facility and permit)?
• In LC-MS/MS, what is the main purpose of using chromatography before mass spectrometry?
• Which statement best describes the qualification for an Analyst?
• What is the significance of matrix-matched calibration in LC-MS/MS assays?
• Why is back-calculation used in calibration curves?
• For a collection device that is unique and integral to the collection and analytical testing, which action is required?
• What is the main outcome of chromatography?
• What are the three mandatory elements of chain-of-custody documentation for a urine drug test sample?
• What is listed as required training to possess as ASC?
• What is carryover and how can it affect sequential samples in an LC-MS/MS run?
• In MS/MS method development, which statement about transitions is accurate?
• To whom should all rejected specimens be reported?
• When do ASC and client/donor/subject affix their signatures on the seal?
• For saliva (Oral Fluid)/ tissue/ fingernails specimens, when is handwashing required relative to collection procedures?
• A hospital-based laboratory establishing a Screening Lab for Drug Testing must provide an additional 20 square meters to its existing floor area. True or False?
• Which strategy helps minimize false negatives in drug screening?
• In immunoassay drug screening, what does cross-reactivity influence?
• How is a data integrity breach typically addressed in a drug testing laboratory?
• What is the primary purpose of a split sample and retest policy in chain of custody?
• If a lab adheres to a 24-hour release policy after specimen submission, what is the maximum time to release results?
• What is the stated minimum size for the work area in a screening laboratory?
• Which analytical technique is commonly used to confirm drug compounds after screening?
• In reporting drug test results, what is the difference between 'Detected' and 'Quantified'?
• Which urine collection is conducted in the absence of ASC or outside the collection site or laboratory and is subjected to specimen validity testing?
• Which statement is consistent with the material about release times?
• How long must a sweat patch be worn?
• What is the most important content of the calibration/maintenance record?
• In LC-MS/MS confirmation, what is the significance of a match in retention time and extracted ion chromatogram (EIC)?
• Which specimen type is specifically associated with a scalp hair sample in collection guidelines?
• Where should a retained specimen be kept?
• In a confirmatory laboratory, the work area must be at least how many square meters?
• What is the minimum floor area indicated for the laboratory facility in the material?
• Define LOD and LOQ and explain how they differ.
• What is the minimum educational level for an Analyst according to the material?
• What is the storage temperature for saliva?
• Which storage condition is described for specimens that are immediately frozen?
• Which urine specimen collection is conducted in the presence of ASC and not subjected to specimen validity testing?
• Which instrument is described as being used to weigh items in the laboratory?
• Which item is included in the Authorized Specimen Collector qualifications related to specimen handling?
• What are the primary roles of GC-MS and LC-MS/MS in confirmatory testing?
• What is the purpose of measuring creatinine in urine drug testing?
• What does linearity mean in method validation, and how is it assessed?
• Within a laboratory quality management system, which element ensures staff competency and training documentation?
• How does SAMHSA guidance influence federally regulated drug testing programs in the United States?
• In a Confirmatory Laboratory, the result must be released within how many hours after submission of the specimen?
• Which term is used to denote the area related to the isolation and handling of samples in the Screening Laboratory?
• Who may cancel a test due to a situation or error?
• Which statement best contrasts the two explicit release windows?
• Which of the following is a tandem mass spectrometry technique used in confirmatory testing?
• Where should scalp hair be stored?
• What outcome arises from proficiency testing review?
• Which attribute is ensured by method validation for a drug panel before deployment?
• Which statements best describe common non-urine specimen types in drug testing and their differences?
• Which statement best describes the 3-5 working days window?
• Compared with urine testing, hair testing typically offers which advantage?
• Which set of components ensures a robust audit trail in a drug testing LIMS?
• What is the minimum quantity required for a scalp hair specimen?
• Which item is included in the qualifications of an Authorized Specimen Collector?
• Name two common quality control materials used in drug testing laboratories for assay validation.
• What does system suitability ensure before running samples?
• Substitution, adulteration, and dilution: what should ASC observe to detect attempts at tampering?
• Which example demonstrates system suitability checks in practice?
• Which item is considered the most important content of the calibration/maintenance record?
• The phrase '3-5 working days' is most likely referring to what aspect of laboratory operations?
• Which metric is typically evaluated to assess linearity in calibration curves?
• What are the typical acceptance criteria for a calibration curve in LC-MS/MS?
• The history of urine quantity collection spans how many days?
• After extraction, what step is often performed to prepare urine samples for GC-MS analysis?
• For urine not stored more than 1 day, what temperature is recommended?
• Retraining of ASC is due to involvement of which entities?
• What is the required floor area for a confirmatory laboratory?
• Which item is listed as an exception for mandatory drug testing (facility and permit)?
• Which instrument is primarily used in confirmatory drug testing to identify specific substances?
• How is identity confirmed in GC-MS?
• What does matrix-matched calibration minimize?
• Which specimen storage requires maceration before storage?